2024-11-14
Transplantation of faecal microbiota: a new weapon against type 2 diabetes?
Endocrinology and Metabolism
FMT as an intervention in type 2 diabetes: a clinical study
21 patients with type 2 diabetes treated with metformin were included in the study and divided into three groups:
- FMT from healthy, lean donors ;
- Probiotic (Lactobacillus delbrueckii LB-14) ;
- Placebo.
The following parameters were measured over a 12-week period: anthropometric variables, blood glucose and HbA1c levels, insulin sensitivity using the HOMA-IR model and the composition of each participant's faecal microbiota.
- FMT does not significantly improve insulin sensitivity or HbA1c in patients with T2DM.
- A moderate increase in HbA1c was observed in patients who received FMT (+0.25%, p = 0.041), but no significant change in glucose or HbA1c levels was observed between the groups.
- The composition of faecal microbiota did not differ between the three treatment groups. However, the microbiota profile changed mainly in favour of the donor species, with no significant impact on insulin sensitivity.
Microbiota transplantation as a therapeutic approach for type II diabetes
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