Homocysteine and mortality in sepsis: a promising predictive biomarker?

Sepsis is an acute inflammatory response to infection, often associated with high mortality despite advances in intensive care. Identifying reliable predictive biomarkers is therefore essential to improve patient management and reduce mortality. Among the biomarkers explored, homocysteine (Hcy) appears to be a potential indicator, due to its role in oxidative stress, endothelial dysfunction and inflammation, essential mechanisms in the pathophysiology of sepsis. This study explores the association between Hcy levels and short-term mortality in patients with sepsis.

The results showed no significant association between Hcy levels and short-term mortality in patients with sepsis. However, subgroup analysis revealed a significant association between elevated Hcy levels and an increased risk of mortality in Chinese patients with sepsis. The absence of a significant correlation between Hcy levels and mortality in non-Asian patients suggests an ethical influence between the relationship between Hcy and mortality in sepsis.