Previous Next
Autoantibodies to contactin-associated protein 2 (anti-CASPR2) cause pain and limbic autoimmune encephalitis. In this study, German researchers analyzed clinical pain data from a large cohort of patients investigating autoimmune encephalitis. Of the 102 patients in the cohort, 36% described frequent pain, 63.6% severe pain and 55.6% pain as their major symptom. Pain phenotypes varied from patient to patient, but the analyses identified two major phenotypes: symmetrical distal burning pain and generalized pain with myalgia and cramps. Certain pre-existing risk factors for chronic pain (diabetes mellitus, peripheral neuropathy, chronic back pain) reinforced the pain picture.

Source(s) :
Patrik Greguletz et al. Different pain phenotypes are associated with anti-Caspr2 autoantibodies. J Neurol. 2024 Feb 22. ;

Last press reviews


COVID-19 and coagulation parameters: a link to mortality?

The COVID-19 pandemic, caused by SARS-CoV-2, has led to millions of deaths...

Resistance training and Multiple Sclerosis: a solution to improve function and quality of life?

Multiple sclerosis (MS) is a chronic autoimmune disease of the central ner...

Endometriosis: the Impact of hormones, sexual practice, and surgical treatments

Endometriosis is a chronic inflammatory disease modulated by estrogen leve...