2024-07-16
High levels of HDL cholesterol reduce the risk of developing low back pain
Endocrinology and Metabolism
This two-sample MR study used data extracted from the public database of the Integrative Epidemiology Unit of the MRC (Medical Research Council). The authors selected three single-nucleotide polymorphisms (SNPs) associated with lipid levels (HDL-C, LDL-C and TG) and two SNPs associated with risk of low back pain (LBP and back pain). These SNPs were used as genetic instrumental variables.
Statistical analyses were performed using several methods, including inverse-variance weighted (IVW), weighted median, MR-Egger, robust adjusted profile score (MR-RAPS) and MR-PRESSO, to examine potential causal associations between lipid levels and risk of LBP.
In conclusion, this study provides important evidence on the role of HDL-C levels in reducing the risk of low back pain, while highlighting the absence of a causal association with LDL-C and TG levels. These results contribute to a better understanding of the metabolic factors involved in low back pain and open up prospects for prevention strategies based on lipid management.
Last press reviews
COVID-19 and coagulation parameters: a link to mortality?
The COVID-19 pandemic, caused by SARS-CoV-2, has led to millions of deaths...
Resistance training and Multiple Sclerosis: a solution to improve function and quality of life?
Multiple sclerosis (MS) is a chronic autoimmune disease of the central ner...
Endometriosis: the Impact of hormones, sexual practice, and surgical treatments
Endometriosis is a chronic inflammatory disease modulated by estrogen leve...