In recent years, surgeons have increasingly used synthetic or biological grafts in transvaginal repairs for vaginal prolapse. This Cochrane review is an update of one published in 2016 and aims to determine the safety and efficacy of transvaginal mesh or biological grafts, compared with native tissue repair or other grafts in the surgical treatment of vaginal prolapse. A total of 51 randomized controlled trials were included, representing 7,846 women. The data suggest that 23% of women still experience symptoms after native tissue repair, a figure ranging from 17% to 22% after permanent mesh repair.
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