Lipoproteins containing apoB and risk of peripheral arterial disease

Elevated levels of lipoproteins containing apoB are a risk factor for atherosclerotic cardiovascular disease, including peripheral arterial disease and myocardial infarction. In this study, Danish researchers analyzed levels of apoB-containing lipoproteins, residual cholesterol and LDL-cholesterol in 93,461 statin-naive patients at baseline. During follow-up of up to 15 years, 1,207 patients developed CAD, 522 developed chronic ischemic limb disease and 2,202 developed myocardial infarction. In the association between increased apoB and increased risk of peripheral arterial disease, residual cholesterol and LDL-cholesterol accounted for 73% and 8% respectively.