Resistance training and Multiple Sclerosis: a solution to improve function and quality of life?

Multiple sclerosis (MS) is a chronic autoimmune disease of the central nervous system, characterized by inflammation, demyelination, and motor impairments that significantly affect quality of life. Despite existing immunomodulatory treatments, chronic fatigue and functional limitations remain largely unaddressed symptoms, highlighting an urgent need for complementary therapies.

In this context, this study explores resistance training (RT) as a non-pharmacological approach to improve muscle strength, functional performance, and quality of life in women with MS.

How does resistance training improve functional abilities and quality of life in MS?

Forty women were selected and divided into three groups:

• Healthy control group (HCON);
• MS group without resistance training (MS+non-RT);
• MS group with resistance training (MS+RT).

Participants were assessed before and after a 12-week intervention. Tests included measurements of muscle strength, functional abilities, and biological markers related to oxidative stress (MDA, SOD, GPx). Quality of life and fatigue were also evaluated using validated questionnaires.

The MS+RT group showed a significant improvement in muscle strength and functional abilities, surpassing both the MS+non-RT and HCON groups. A notable reduction in fatigue and an improvement in quality of life were also observed in this group. However, changes in oxidative stress markers were not significant, suggesting that the benefits of resistance training may be more closely related to physiological and functional mechanisms rather than modulation of oxidative stress.

Resistance training: a promising path to transform MS management

This study highlights the benefits of structured and supervised resistance training in improving motor functions, reducing fatigue, and enhancing quality of life in women with MS. While the effects on oxidative stress require further investigation, the findings suggest that muscle strengthening could be a key strategy in the personalized management of this complex disease.