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Until now, no treatment has shown superior efficacy to platinum-based chemotherapy in improving overall survival in patients with treatment-naive locally advanced or metastatic urothelial carcinoma. In this phase 3 clinical trial, investigators compared the efficacy and safety of enfortumab and pembrolizumab to platinum-based chemotherapy in 886 patients with previously untreated locally advanced or metastatic urothelial carcinoma. Progression-free survival and overall survival were longer in the enfortumab - pembrolizumab arm than in the chemotherapy arm. The median number of treatment cycles was 12 in the enfortumab - pembrolizumab arm, and 6 in the chemotherapy arm. 

Source(s) :
Thomas Powles et al. Enfortumab Vedotin and Pembrolizumab in Untreated Advanced Urothelial Cancer. N Engl J Med. 2024 Mar 7;390(10):875-888. ;

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