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2024-03-01

Detection of high-risk HPV viruses

Infectiology

The detection of high-risk HPV viruses is crucial for the prevention and early detection of cervical cancer. In this study, researchers evaluated the value of a sample genotyping system compared with the traditional real-time PCR method. They randomly selected 365 samples (representing 7,259 women) after running them through real-time PCR, which they then analyzed using the fully automated GenPlex® system. This system identifies 24 HPV virus types using a combination of PCR and microarray-based reverse hybridization. From the real-time PCR, 76 were negative for high-risk HPV, and 289 were positive. The GenPlex® system identified a larger number of positive cases, 73 with a type of HPV not covered by real-time PCR, and 20 potentially due to a DNA concentration undetectable by PCR.

Source(s) :
: Lijuan Zhang et al. Analytical evaluation of the automated genotyping system (GenPlex) compared to a traditional real-time PCR assay for the detection of high-risk human papillomaviruses. J Med Virol. 2024 Mar;96(3):e29496. ;

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