Researchers here have synthesized a prodrug, squalenoyl-chidamide, binding lipophilic squalene to the hydrophilic antitumor drug chidamide via trypsin-sensitive binding. The nanoparticles developed showed significantly higher in vitro drug release in 0.5% trypsin medium, compared with release in trypsin-free medium. In vitro cellular uptake tests revealed a two- to four-fold higher permeation of nanoparticles into the tumor spheres of pancreatic tumor cells. After intraperitoneal administration to mice with subcutaneous tumors, these nanoparticles demonstrated significant efficacy against pancreatic cancer, inducing apoptosis of cancer cells and inhibiting their proliferation in vivo.
Last press reviews
Gut microbiota is involved in the progression of non-alcoholic fatty liver disease
Non-alcoholic fatty liver disease (NAFLD) is characterized by an accum...
Elderly women with depression have a higher prevalence of low back pain
Low back pain is a pain in the lumbar vertebrae at the base of the bac...
The renin-angiotensin system in the human brain
The renin-angiotensin system is a hormonal system that regulates blood...