Press reviews
2024-10-17
Association between intestinal microbiota and diabetic nephropathy: a two-sample randomization study
Urology-nephrology
Source(s) :
Shisheng Han, Yinqing Chen, Yan Lu, Meng Jia, Yanqiu Xu, Yi Wang
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2024-10-17
Urology-nephrology
The authors obtained data on bladder cancer (373,295 cases and 372,016 controls), prostate cancer (462,933 cases and 459,664 controls) and kidney cancer (463,010 cases and 461,896 controls) from the UK Biobank.
Genetic variations linked to 41 circulating cytokines were used as instrumental variables in meta-analyses of genome-wide association studies (GWAS) involving 8,293 Finnish individuals. The authors mainly used the inverse variance weighted (IVW) method to assess potential associations between the 41 cytokines and the risk of 3 common urological cancers. The weighted median, weighted mode and simple median methods were used to assess sensitivity. Heterogeneity and pleiotropic outliers were assessed by Cochran's Q test and MR-Egger regression. Genetic correlation, colocalization analysis and MR multivariate analysis were used to validate potential pleiotropy.
After Bonferroni correction, an association was observed between genetically predicted high CCL27 levels and an increased risk of bladder cancer. Conversely, IL-12p70 levels were found to have a protective association against bladder cancer risk. Sensitivity analyses using various IV sets and the MR approach remained robust. In addition, the authors found potential associations between 7 cytokines and urological cancers (4.07 × 10-4 ≤ P < 0.05).
Conclusion: this study confirmed causal associations between CCL27, IL-12p70 and bladder cancer risk, as well as potential associations of 7 cytokines with urological cancer risk. This helps us to better understand the pathogenesis of urological cancers and provides clues for improving diagnostic accuracy and therapies.
Source(s) :
Chanson Jinbo, Soleil Xiaoke, Ting Wang, Chao Li, Leihong Yuan
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2024-10-17
pneumonology
Data were collected through the National Health and Nutrition Examination Survey (NHANES) between January 1999 and December 2018. The method for calculating NLR is to divide the number of neutrophils by the number of lymphocytes in the total number of blood cells. The optimal NLR threshold for survival results was determined using the statistical method of Maximum Selected Ranks (MSRSM). The relationship between NLR and risk of all-cause mortality and cardiovascular mortality in COPD was investigated using a multivariate Cox regression model. In addition, the restricted cubic spline (RCS) was used to discuss the potential relationship between NLR patients in different groups and mortality risk.
In this study, 716 adults with COPD were included using the statistical method of the maximum selected ranks, of which 208 had a higher NLR ( 2.56) and 508 a lower NLR (<2.56). Over a median follow-up of 111.5 months, 162 patients with COPD died from all causes and 49 patients died from cardiovascular disease. After adjustment for demographic, socio-economic and lifestyle factors, the risk of all-cause mortality (HR = 2.07, 95%CI: 1.46-2.94) and cardiovascular mortality (HR = 3.03, 95%CI: 1.63-5.65) in patients with high NLR was 2- or 3-fold higher than those with lower NLR.
Source(s) :
Zhao Chen, Wenqiang Li, Yuanchun Tang, Peng Zhou, Qian He, Zhiping Deng
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2024-10-15
Dermatology and Venereology
Physicians are challenged to find unique and extremely rare TAP patients/families among the millions of individuals with common allergic diseases.
The authors describe case scenarios with characteristic TAPs. They reviewed the literature and derived specific clinical warning signs for TAP detection. These include positive family history and/or signs of pathological susceptibility to infections, immunodysregulation or syndromic disease.
The results of conventional laboratory tests and most immunological studies are not sufficient to establish a definitive diagnosis of TAP. In the past, the multi-step reduction of differential diagnoses by various immunological and other laboratory tests led to single-gene or gene panel testing, an approach that was time consuming and often unsuccessful.
The implementation of comprehensive genomic analyses in routine diagnostics has led to a paradigm shift. Early Genome Sequencing (WGS) will shorten the diagnostic time, save patients from unnecessary investigations and reduce morbidity and mortality.
The authors propose a rational, clinical-landmark approach to deciding which cases pass the filter of early whole genome analysis.
Source(s) :
Tim Niehues, Sandra von Hardenberg, Eunike Velleuer
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2024-10-15
Endocrinology and metabolism
Source(s) :
Xiao-Dong Zhou
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2024-10-15
Iron homeostasis and ferroptosis in human diseases: mechanisms and therapeutic perspectives
Pharmacology and toxicology
Source(s) :
Qin Ru, Yusheng Li, Lin Chen, Yuxiang Wu, Junxia Min, Fudi Wang
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2024-09-26
Urology-nephrology
CONCLUSION: Medroxyprogesterone acetate combined with metformin is the most effective treatment for endometrial hyperplasia. For patients who have difficulty taking their medication regularly, the levonorgestrel-releasing intrauterine system combined with metformin is an effective alternative treatment.
Source(s) :
Yao Y, Xu S, Wang T, Jiang R
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2024-09-26
Neurology
Results: 137 randomised controlled trials involving 89,445 participants allocated to one of the 17 compounds or placebo were included. All compounds showed superior efficacy to placebo for pain relief at 2 hours (odds ratios ranging from 1.73 (95% confidence interval [CI] 1.27 to 2.34) for naratriptan to 5.19 (4, 25 to 6.33) for eletriptan), and most of them also for maintaining pain relief after 24 hours (odds ratios from 1.71 (1.07 to 2.74) for celecoxib to 7.58 (2.58 to 22.27) for ibuprofen). In direct comparisons between active molecules, eletriptan was the most effective drug in relieving pain after two hours (odds ratios from 1.46 (1.18 to 1.81) to 3.01 (2.13 to 4.25)), followed by rizatrix (2.13 to 4.25) and ibuprofen. 25)), followed by rizatriptan (1.59 (1.18 to 2.17) to 2.44 (1.75 to 3.45)), sumatriptan (1.35 (1.03 to 1.75) to 2.04 (1.49 to 2.86)) and zolmitriptan (1.47 (1.04 to 2.08) to 1.96 (1.39 to 2.86)). For lasting pain relief, the most effective molecules were eletriptan and ibuprofen (odds ratios from 1.41 (1.02 to 1.93) to 4.82 (1.31 to 17.67)). Confidence in CINeMA ranged from high to very low. Sensitivity analyses looking only at Food and Drug Administration-approved doses, high versus low doses, risk of bias, and moderate to severe headache at baseline confirmed the main findings for the primary and secondary endpoints.
2024-09-26
Folate intake and the risk of endometrial cancer: a dose-response meta-analysis
Urology-nephrology Oncology
Source(s) :
Long J ; Wang D ; Yang M ; Pang Y ; Li M ; Qin S ; Cui K
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2024-09-24
Dermatology and Venereology
Source(s) :
Huang L ; Zhao D ; Lin H ; Zheng H ; Li X ; Chen L ; Tang P
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2024-09-24
Endocrinology and metabolism Neurology
Source(s) :
Ting Xu, Yuan Zhuang, Huabin Cao, Jingqi Yang
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2024-09-24
Rhumatology
Source(s) :
Zhixiang Zhang , Zhiqiang Shao , Zonghan Xu, Jiaqian Wang
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2024-09-18
Neurology
Source(s) :
Habibzadeh A ; Ostovan VR ; Ghezel MA ; Kavari K ; Kardeh S ; Tabrizi R
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2024-09-18
Gastroenterology and Hepatology
In addition, ChIP-seq analysis revealed that vitexin regulates transcriptional activation of the phenazine biosynthesis domain protein (PBLD) via VDR. ChIP and dual luciferase reporter assays were used to identify the functional regulatory region of PBLD, confirming that the VDR/PBLD pathway is essential for the regulation of vitexin-mediated macrophage polarisation.
2024-09-18
Chronic endometritis and recurrent reproductive failure: a systematic review and meta-analysis
Urology-nephrology
Source(s) :
Ticconi C; Inversetti A; Marraffa S; Campagnolo L; Arthur J; Zambella E; Di Simone N
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